July 9, 2024, Vol 332, No. 2, Pages 89-178

In This Issue of JAMA

Audio Highlights

Abstract Full Text

free access online only has audio

JAMA. 2024;332(2):e2318339. doi:10.1001/jama.2023.18339

Audio: EEG-Guided Anesthesia and Delirium, Integrating Clinical Trials With Clinical Practice, Depression Review, and more

Original Investigation

Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery: The ENGAGES-Canada Randomized Clinical Trial

Alain Deschamps, MD, PhD; Arbi Ben Abdallah, PhD; Eric Jacobsohn, MD, ChB; et al.

Abstract Full Text

JAMA. 2024;332(2):112-123. doi:10.1001/jama.2024.8144

This randomized clinical trial examines whether electroencephalogram -guided anesthesia decreases the incidence of delirium after cardiac surgery among adults 60 years or older.

Editorial
Anesthesia Dose and Delirium—A Picture Coming Into Focus
Miles Berger, MD, PhD; Mark D. Neuman, MD, MSc

JAMA

Association Between Cost Sharing and Naloxone Prescription Dispensing

Kao-Ping Chua, MD, PhD; Rena M. Conti, PhD; Pooja Lagisetty, MD; et al.

Abstract Full Text

JAMA. 2024;332(2):124-132. doi:10.1001/jama.2024.8378

This study evaluates the association between cost sharing and naloxone prescription abandonment (nondispensing of naloxone prescriptions) in commercial insurance and Medicare plans.

Editorial
Costs and Essential Drug Access—The Case of Naloxone
Leo Beletsky, JD, MPH; Max Jordan Nguemeni Tiako, MD, MS

JAMA

Mortality and Morbidity in Adults With Rheumatic Heart Disease

Ganesan Karthikeyan, DM; Mpiko Ntsekhe, PhD; Shofiqul Islam, PhD; et al.

Abstract Full Text

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JAMA. 2024;332(2):133-140. doi:10.1001/jama.2024.8258

This prospective observational study investigates mortality rates and predictive risk factors for rheumatic heart disease in 24 endemic low- and middle-income countries and evaluates interventions like corrective valve surgery and valvuloplasty.

Editorial
Rheumatic Heart Disease—A Neglected Tragedy in Young Patients
Kumar Narayanan, MD; Eloi Marijon, MD, PhD

JAMA Cardiol

Research Letter

Trends in Naloxone Dispensing From Retail Pharmacies in the US

S. Michaela Rikard, PhD; Andrea E. Strahan, PhD; Lyna Z. Schieber, MD, DPhil; et al.

Abstract Full Text

JAMA. 2024;332(2):165-167. doi:10.1001/jama.2024.8323

This cross-sectional study examines trends in naloxone dispensing by US retail pharmacies from 2019 to 2023, including prescriber specialty and product brand.

Trends in Preeclampsia Risk Factors in the US From 2010 to 2021

Mariam K. Ayyash, MD, MSCR; Rodney McLaren Jr, MD; Majid Shaman, MD; et al.

Abstract Full Text

JAMA. 2024;332(2):167-169. doi:10.1001/jama.2024.8931

This population-based retrospective study uses data from the National Vital Statistics System to evaluate trends in risk factors for preeclampsia in the US between 2010 and 2021.

Special Communication

Integrating Clinical Trials and Practice

The Integration of Clinical Trials With the Practice of Medicine: Repairing a House Divided

Derek C. Angus, MD, MPH; Alison J. Huang, MD, MAS; Roger J. Lewis, MD, PhD; et al.

Abstract Full Text

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JAMA. 2024;332(2):153-162. doi:10.1001/jama.2024.4088

This Special Communication discusses the need for better integration of clinical trials and health care delivery enterprises.

Audio: Integrating Clinical Trials With the Practice of Medicine

Editorial
Introducing the JAMA Summit
Kirsten Bibbins-Domingo, PhD, MD, MAS; Derek C. Angus, MD, MPH; Hannah Park; Roger J. Lewis, MD, PhD; Rohan Khera, MD, MS; Jennifer Zeis; Annette Flanagin, RN, MA; Gregory Curfman, MD

JAMA
Editor's Note
Integrating Clinical Trials and Practice: A New JAMA Series and Call for Papers
Gregory Curfman, MD

JAMA

Viewpoint

Health and the 2024 US Election

Early Pregnancy Loss in an Era of “Wrongful Embryonic Death”

Allen J. Wilcox, MD, PhD; Lisa C. Ikemoto, JD, LLM

Abstract Full Text

JAMA. 2024;332(2):99-100. doi:10.1001/jama.2024.7403

This Viewpoint examines the possible legal consequences of pregnancy loss following the Alabama Supreme Court’s decision to extend personhood to laboratory-conceived embryos.

Upholding Standards for Qualified Bilingual Staff

Adaugo Amobi, MD, MPH

Abstract Full Text

JAMA. 2024;332(2):101-102. doi:10.1001/jama.2024.8896

This Viewpoint discusses ways to ensure the proficiency of bilingual communication among health care staff in patient-clinician encounters, such as language testing and use of professional interpreters.

Integrating Clinical Trials and Practice

Why Should the FDA Focus on Pragmatic Clinical Research?

Ali B. Abbasi, MD; Lesley H. Curtis, PhD; Robert M. Califf, MD

Abstract Full Text

JAMA. 2024;332(2):103-104. doi:10.1001/jama.2024.6227

This Viewpoint from the FDA discusses how pragmatic clinical research—assessment that uses real-world data, often in combination with research data, after initial marketing approval—can help in evaluation of new technologies, benefit research sites in underresourced settings, and better inform regulatory decisions and clinical practice.

Editor's Note
Integrating Clinical Trials and Practice: A New JAMA Series and Call for Papers
Gregory Curfman, MD

JAMA

A Piece of My Mind

The Weight of a Differential

Maren E. Olson, MD, MPH, MEd

Abstract Full Text

JAMA. 2024;332(2):105-106. doi:10.1001/jama.2024.8766

In this narrative medicine essay, when a physician’s mother begins experiencing postmenopausal bleeding, the author wonders what it would be like to hear someone’s signs and symptoms and not automatically begin to build a differential.

Editorial

Anesthesia Dose and Delirium—A Picture Coming Into Focus

Miles Berger, MD, PhD; Mark D. Neuman, MD, MSc

Abstract Full Text

JAMA. 2024;332(2):107-108. doi:10.1001/jama.2023.26819

Costs and Essential Drug Access—The Case of Naloxone

Leo Beletsky, JD, MPH; Max Jordan Nguemeni Tiako, MD, MS

Abstract Full Text

JAMA. 2024;332(2):109-110. doi:10.1001/jama.2024.7012

Review

Management of Depression in Adults: A Review

Gregory E. Simon, MD, MPH; Nathalie Moise, MD, MS; David C. Mohr, PhD

Abstract Full Text

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JAMA. 2024;332(2):141-152. doi:10.1001/jama.2024.5756

This narrative review uses data from network meta-analyses and systematic reviews to explore the prevalence, diagnosis, and treatment of major depression in US adults, including specific forms of psychotherapy and more than 20 antidepressant medications.

Audio: Managing Depression in Adults

JAMA Guide to Statistics and Methods

Test-Negative Study Designs for Evaluating Vaccine Effectiveness

Natalie Dean, PhD; Avnika B. Amin, PhD

Abstract Full Text

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JAMA. 2024;332(2):163-164. doi:10.1001/jama.2024.5633

This JAMA Guide to Statistics and Methods article explains the test-negative study design, an observational study design routinely used to estimate vaccine effectiveness, and examines its use in a study that estimated the performance of messenger RNA boosters against the Omicron variant.

Editor's Note

Integrating Clinical Trials and Practice

Integrating Clinical Trials and Practice: A New JAMA Series and Call for Papers

Gregory Curfman, MD

Abstract Full Text

free access

JAMA. 2024;332(2):111. doi:10.1001/jama.2024.10266

Poetry and Seeing the Sacred in Medicine

Rafael Campo, MD, MA

Abstract Full Text

JAMA. 2024;332(2):174. doi:10.1001/jama.2024.7221

Medical News & Perspectives

Syphilis Has Surged for Reasons That Go Beyond the Pathogen That Causes It

Rita Rubin, MA

Abstract Full Text

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JAMA. 2024;332(2):92-95. doi:10.1001/jama.2024.2978

This Medical News story discusses the multiple factors contributing to the resurgence of syphilis in the US.

Audio: June 2024 Medical News Summary

Medical News in Brief

AAP Changes Its Breastfeeding Policy for People With HIV in US

Emily Harris

Abstract Full Text

JAMA. 2024;332(2):96. doi:10.1001/jama.2024.10335

Counting Minutes, Steps Linked With Similar Mortality Reduction

Emily Harris

Abstract Full Text

JAMA. 2024;332(2):96. doi:10.1001/jama.2024.10336

Editor's Note
Tracking Physical Activity One Step at a Time
Cary P. Gross, MD; Raegan W. Durant, MD, MPH

JAMA Intern Med

Rare Inherited Tumor Syndrome Tied to Nail Condition

Emily Harris

Abstract Full Text

JAMA. 2024;332(2):96. doi:10.1001/jama.2024.10337

Progestogen May Lower Risk for More Surgery for Endometriosis Pain

Emily Harris

Abstract Full Text

JAMA. 2024;332(2):96. doi:10.1001/jama.2024.10338

Having Peers With Mental Disorders Might Increase Classmates’ Risk

Emily Harris

Abstract Full Text

JAMA. 2024;332(2):96-97. doi:10.1001/jama.2024.10339

Fish Oil Pills Associated With Increased Risk of Heart Problems in Healthy People

Emily Harris

Abstract Full Text

JAMA. 2024;332(2):97. doi:10.1001/jama.2024.10340

Cognitive Impairment Underestimated Among American Indian People

Emily Harris

Abstract Full Text

JAMA. 2024;332(2):97. doi:10.1001/jama.2024.10341

Early Therapy for Symptomatic COPD, Asthma Improved Quality of Life

Emily Harris

Abstract Full Text

JAMA. 2024;332(2):97. doi:10.1001/jama.2024.10342

Review Calls for Standardized Long COVID Definition

Emily Harris

Abstract Full Text

JAMA. 2024;332(2):97. doi:10.1001/jama.2024.10343

Poetry and Medicine

Radiance

Ronnie Sirmans, ABJ

Abstract Full Text

JAMA. 2024;332(2):174. doi:10.1001/jama.2024.7205

Editor's Note
Poetry and Seeing the Sacred in Medicine
Rafael Campo, MD, MA

JAMA

JAMA Revisited

The Conquest of Yellow Fever

Abstract Full Text

JAMA. 2024;332(2):175. doi:10.1001/jama.2023.18340

JAMA Patient Page

What Is Lynch Syndrome?

Kasey Hornbuckle, MD; Cassandra D. L. Fritz, MD, MPHS

Abstract Full Text

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JAMA. 2024;332(2):178. doi:10.1001/jama.2024.8552

This JAMA Patient Page describes Lynch syndrome, its risk factors and diagnosis, and its association with colorectal cancer and other specific cancers.

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