David Tougeron, MD, PhD; Laetitia Dahan, MD, PhD; Ludovic Evesque, MD; et al.
open access
JAMA Oncol. 2024;10(6):709-717. doi:10.1001/jamaoncol.2024.0207
This randomized clinical trial examines the efficacy of 1 or 2 immune checkpoint inhibitors combined with FOLFIRI in the treatment of advanced gastric/GEJ adenocarcinoma.
Kristen D. Brantley, PhD, MPH; Shoshana M. Rosenberg, ScD, MPH; Laura C. Collins, MD; et al.
JAMA Oncol. 2024;10(6):718-725. doi:10.1001/jamaoncol.2024.0286
This cohort study examines the risk of a second primary breast cancer in women who were aged 40 years or younger when first diagnosed with breast cancer.
Jeffrey J. Tosoian, MD, MPH; Yuping Zhang, PhD; Lanbo Xiao, PhD; et al.
open access
JAMA Oncol. 2024;10(6):726-736. doi:10.1001/jamaoncol.2024.0455
This report describes the development of an 18-gene urine panel for high-grade prostate cancer and validates its external performance relative to current guideline-endorsed biomarkers.
Won Kyung Cho, MD; Won Park, MD; Sang-Won Kim, MD; et al.
JAMA Oncol. 2024;10(6):737-743. doi:10.1001/jamaoncol.2024.0565
This nonrandomized controlled trial investigates the acute toxic effects of treatment with hypofractionated pelvic intensity-modulated radiotherapy and concurrent chemotherapy among women who experienced lymph node metastasis, parametrial invasion, or positive resection margins after radical hysterectomy for treatment of confirmed cervical cancer.
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Invited Commentary
Interpreting the Findings of the POHIM-CCRT Trial
Mark E. Bernard, MD
JAMA Oncol
Tamás Fazekas, MD; Sung Ryul Shim, MPH, PhD; Giuseppe Basile, MD; et al.
JAMA Oncol. 2024;10(6):745-754. doi:10.1001/jamaoncol.2024.0734
This systematic review and meta-analysis examines evidence regarding screening pathways incorporating magnetic resonance imaging with targeted biopsy and assess their diagnostic value compared with prostate-specific antigen–based screening with systematic biopsy strategies.
Marc-Oliver Grimm, MD; Martin Schostak, MD, PhD; Christine Barbara Grün, MD; et al.
JAMA Oncol. 2024;10(6):755-764. doi:10.1001/jamaoncol.2024.0938
This nonrandomized clinical trial evaluates the efficacy and safety of a tailored approach with nivolumab plus ipilimumab as an immunotherapeutic boost in patients with metastatic urothelial carcinoma.
Amy Ming-Fang Yen, PhD; Chen-Yang Hsu, PhD; Ting-Yu Lin, PhD; et al.
open access
JAMA Oncol. 2024;10(6):765-772. doi:10.1001/jamaoncol.2024.0961
This cohort study examines the applicability of personalized colorectal cancer (CRC) screening with fecal-hemoglobin (f-Hb)-guided screening intervals to reduce the number of fecal immunological tests and colonoscopy, as well as determine if it demonstrates equivalent efficacy as universal biennial screening.
Tafadzwa L. Chaunzwa, MD; Jack M. Qian, MD; Qin Li, PhD; et al.
JAMA Oncol. 2024;10(6):773-783. doi:10.1001/jamaoncol.2024.1120
This cohort study examines the association of body composition with oncologic outcomes in patients receiving immunotherapy for advanced or metastatic non–small cell lung cancer.