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June 2024, Vol 10, No. 6, Pages 697-835

Original Investigation

FOLFIRI Plus Durvalumab With or Without Tremelimumab in Second-Line Treatment of Advanced Gastric or Gastroesophageal Junction Adenocarcinoma: The PRODIGE 59-FFCD 1707-DURIGAST Randomized Clinical Trial

Abstract Full Text
open access
JAMA Oncol. 2024;10(6):709-717. doi:10.1001/jamaoncol.2024.0207

This randomized clinical trial examines the efficacy of 1 or 2 immune checkpoint inhibitors combined with FOLFIRI in the treatment of advanced gastric/GEJ adenocarcinoma.

Second Primary Breast Cancer in Young Breast Cancer Survivors

Abstract Full Text
JAMA Oncol. 2024;10(6):718-725. doi:10.1001/jamaoncol.2024.0286

This cohort study examines the risk of a second primary breast cancer in women who were aged 40 years or younger when first diagnosed with breast cancer.

Development and Validation of an 18-Gene Urine Test for High-Grade Prostate Cancer

Abstract Full Text
open access
JAMA Oncol. 2024;10(6):726-736. doi:10.1001/jamaoncol.2024.0455

This report describes the development of an 18-gene urine panel for high-grade prostate cancer and validates its external performance relative to current guideline-endorsed biomarkers.

Postoperative Hypofractionated Intensity-Modulated Radiotherapy With Concurrent Chemotherapy in Cervical Cancer: The POHIM-CCRT Nonrandomized Controlled Trial

Abstract Full Text
JAMA Oncol. 2024;10(6):737-743. doi:10.1001/jamaoncol.2024.0565

This nonrandomized controlled trial investigates the acute toxic effects of treatment with hypofractionated pelvic intensity-modulated radiotherapy and concurrent chemotherapy among women who experienced lymph node metastasis, parametrial invasion, or positive resection margins after radical hysterectomy for treatment of confirmed cervical cancer.

Magnetic Resonance Imaging in Prostate Cancer Screening: A Systematic Review and Meta-Analysis

Abstract Full Text
JAMA Oncol. 2024;10(6):745-754. doi:10.1001/jamaoncol.2024.0734

This systematic review and meta-analysis examines evidence regarding screening pathways incorporating magnetic resonance imaging with targeted biopsy and assess their diagnostic value compared with prostate-specific antigen–based screening with systematic biopsy strategies.

Nivolumab + Ipilimumab as Immunotherapeutic Boost in Metastatic Urothelial Carcinoma: A Nonrandomized Clinical Trial

Abstract Full Text
JAMA Oncol. 2024;10(6):755-764. doi:10.1001/jamaoncol.2024.0938

This nonrandomized clinical trial evaluates the efficacy and safety of a tailored approach with nivolumab plus ipilimumab as an immunotherapeutic boost in patients with metastatic urothelial carcinoma.

Precision Colorectal Cancer Fecal Immunological Test Screening With Fecal-Hemoglobin-Concentration–Guided Interscreening Intervals

Abstract Full Text
open access
JAMA Oncol. 2024;10(6):765-772. doi:10.1001/jamaoncol.2024.0961

This cohort study examines the applicability of personalized colorectal cancer (CRC) screening with fecal-hemoglobin (f-Hb)-guided screening intervals to reduce the number of fecal immunological tests and colonoscopy, as well as determine if it demonstrates equivalent efficacy as universal biennial screening.

Body Composition in Advanced Non-Small Cell Lung Cancer Treated With Immunotherapy

Abstract Full Text
JAMA Oncol. 2024;10(6):773-783. doi:10.1001/jamaoncol.2024.1120

This cohort study examines the association of body composition with oncologic outcomes in patients receiving immunotherapy for advanced or metastatic non–small cell lung cancer.

Brief Report

Patient-Reported Outcomes as a Recruitment Strategy for Clinical Trial Enrollment

Abstract Full Text
JAMA Oncol. 2024;10(6):784-788. doi:10.1001/jamaoncol.2024.0280

This study examines the association between electronic patient-reported outcome–prompted recruitment strategies and clinical trial enrollment.

Adherence to American Cancer Society Nutrition and Physical Activity Guidelines Among Cancer Survivors

Abstract Full Text
JAMA Oncol. 2024;10(6):789-792. doi:10.1001/jamaoncol.2024.0470

This cross-sectional study uses data from the Behavioral Risk Factor Surveillance System to evaluate adherence to the American Cancer Society (ACS) nutrition and physical activity guidelines among cancer survivors.

Omission of Axillary Dissection Following Nodal Downstaging With Neoadjuvant Chemotherapy

Abstract Full Text
JAMA Oncol. 2024;10(6):793-798. doi:10.1001/jamaoncol.2024.0578

This cohort study examines oncological outcomes after sentinel lymph node biopsy with dual-tracer mapping or targeted axillary dissection.

Research Letter

Allogeneic CD19/CD22 CAR T-Cell Therapy for B-Cell Acute Lymphoblastic Leukemia

Abstract Full Text
open access
JAMA Oncol. 2024;10(6):821-824. doi:10.1001/jamaoncol.2024.0473

This case series reports durable remissions in 2 patients with relapsed/refractory B-cell acute lymphoblastic leukemia treated with allogeneic bispecific CD19/CD22-targeting chimeric antigen receptor T cells.

Gefitinib vs Gefitinib Plus Pemetrexed and Carboplatin Chemotherapy in EGFR-Variant Lung Cancer—Long-Term Results of a Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. 2024;10(6):824-826. doi:10.1001/jamaoncol.2024.0584

This randomized clinical trial examines whether adding chemotherapy with pemetrexed and carboplatin to gefitinib improves survival among patients with epidermal growth factor receptor (EGFR)–variant non–small cell lung cancer.

T-Cell Malignant Neoplasms After Chimeric Antigen Receptor T-Cell Therapy

Abstract Full Text
has audio
JAMA Oncol. 2024;10(6):826-828. doi:10.1001/jamaoncol.2024.0662

This cohort study assesses the increase in second primary malignant neoplasms and T-cell malignant neoplasm cases associated with chimeric antigen receptor–T cells.

Special Communication

American Radium Society Appropriate Use Criteria for Unresectable Locally Advanced Non–Small Cell Lung Cancer

Abstract Full Text
has active quiz
JAMA Oncol. 2024;10(6):799-806. doi:10.1001/jamaoncol.2024.0294

This Special Communication discusses case-referenced consensus and evidence-based guidelines to inform clinical practice in unresectable locally advanced non–small cell lung cancer (NSCLC).

Review

Metastatic Hormone-Sensitive Prostate Cancer and Combination Treatment Outcomes: A Review

Abstract Full Text
has active quiz
JAMA Oncol. 2024;10(6):807-820. doi:10.1001/jamaoncol.2024.0591

This review assesses current evidence and emerging treatment strategies for improved survival among patients with metastatic hormone-sensitive prostate cancer and offers recommendations for clinical practice application.

Viewpoint

Ovarian Cancer Isn’t Just a White Woman’s Disease

Abstract Full Text
JAMA Oncol. 2024;10(6):697-698. doi:10.1001/jamaoncol.2024.0191

This Viewpoint highlights the need for recognition that ovarian cancer affects women from racial and ethnic minority groups worldwide and that the rates of ovarian cancer are increasing in those populations while decreasing among White women.

Using Nerve Blocks for Addressing Radiation-Induced Pain During Pelvic Cancer Treatment

Abstract Full Text
JAMA Oncol. 2024;10(6):698-699. doi:10.1001/jamaoncol.2024.0304

This Viewpoint discusses the use of nerve blocks for pain during pelvic cancer treatment.

Policy Priorities in Cancer Care for Transgender People

Abstract Full Text
JAMA Oncol. 2024;10(6):699-701. doi:10.1001/jamaoncol.2024.0451

This Viewpoint calls for health care systems, oncologists, and staff to prioritize and adopt policies that are inclusive and respectful of transgender patients with cancer.

Editorial

Immunotherapy in Gastric Cancer—Choosing Methods or Results

Abstract Full Text
JAMA Oncol. 2024;10(6):704-705. doi:10.1001/jamaoncol.2023.7262

USPSTF Breast Cancer Screening Guidelines Do Not Go Far Enough

Abstract Full Text
JAMA Oncol. 2024;10(6):706-708. doi:10.1001/jamaoncol.2024.0905
Invited Commentary

Interpreting the Findings of the POHIM-CCRT Trial

Abstract Full Text
JAMA Oncol. 2024;10(6):743-744. doi:10.1001/jamaoncol.2024.0048
Cancer Care Chronicles

Lessons in Truth-Telling From the Novels of Thomas Wolfe

Abstract Full Text
JAMA Oncol. 2024;10(6):702-703. doi:10.1001/jamaoncol.2024.0597

This essay describes the author’s experience with learning about building trust with every patient and family interaction through literature.

Poetry and Oncology

The Metastatic Waltz

Abstract Full Text
JAMA Oncol. 2024;10(6):835. doi:10.1001/jamaoncol.2024.0314
Comment & Response

Locally Advanced Relapse May Not Be Equal to Stage 3 Non–Small Cell Lung Cancer

Abstract Full Text
JAMA Oncol. 2024;10(6):828-829. doi:10.1001/jamaoncol.2024.0231

Locally Advanced Relapse May Not Be Equal to Stage 3 Non–Small Cell Lung Cancer—Reply

Abstract Full Text
JAMA Oncol. 2024;10(6):829-830. doi:10.1001/jamaoncol.2024.0234

Local Immunoradiotherapy in Patients With Metastatic Soft-Tissue Sarcoma

Abstract Full Text
JAMA Oncol. 2024;10(6):830. doi:10.1001/jamaoncol.2024.0308

Local Immunoradiotherapy in Patients With Metastatic Soft-Tissue Sarcoma—Reply

Abstract Full Text
JAMA Oncol. 2024;10(6):830-831. doi:10.1001/jamaoncol.2024.0311

Clarification Regarding Breast Cancer Stage in France

Abstract Full Text
JAMA Oncol. 2024;10(6):831-832. doi:10.1001/jamaoncol.2024.0668

Clarification Regarding Breast Cancer Stage in France—Reply

Abstract Full Text
JAMA Oncol. 2024;10(6):832-833. doi:10.1001/jamaoncol.2024.0671
Correction

Error in Figure

Abstract Full Text
free access
JAMA Oncol. 2024;10(6):833. doi:10.1001/jamaoncol.2024.1062
JAMA Oncology Masthead

JAMA Oncology

Abstract Full Text
free access
JAMA Oncol. 2024;10(6):No Pagination Specified. doi:10.1001/jamaoncol.2023.4648
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